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Histone deacetylase inhibitors: New treatment options for inflammatory joint disease?

✍ Scribed by Éric Toussirot; Kashif Aziz Khan; Ewa Bertolini; Daniel Wendling; Georges Herbein

Book ID
113684876
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
160 KB
Volume
77
Category
Article
ISSN
1297-319X

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## Abstract Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylatio