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Pharmacological inhibition of histone deacetylases for the treatment of cancer, neurodegenerative disorders and inflammatory diseases

✍ Scribed by Bonfils, Claire; Walkinshaw, Donald R; Besterman, Jeffrey M; Yang, Xiang-Jiao; Li, Zuomei

Book ID
126485527
Publisher
Informa plc
Year
2008
Tongue
English
Weight
497 KB
Volume
3
Category
Article
ISSN
1746-0441

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## Abstract Histone deacetylases (HDACs) are involved in chromatin remodeling and modification of nonhistone transcription regulatory proteins, thus modulating the expression of genes important for complex biological events. Dysregulation of HDACs and aberrant chromatin acetylation and deacetylatio