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Hexafluoroacetone as Protecting and Activating Reagent: An Efficient Strategy for Activation of Pyroglutamic Acid and Homologues.

✍ Scribed by Ksenia Pumpor; Christoph Boettcher; Susanna Fehn; Klaus Burger


Publisher
John Wiley and Sons
Year
2004
Weight
130 KB
Volume
35
Category
Article
ISSN
0931-7597

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Synthesis of heteroaryl substituted Ξ±-me
✍ Ksenia Pumpor; Elisabeth Windeisen; Klaus Burger πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 99 KB

## Abstract The synthesis of heterocyclic α‐mercapto acids starting from (__RS__)‐thiomalic acid using hexafluoroacetone as protecting and activating agent is described. The new compounds are useful building blocks for peptide and depsipeptide modification as well as for drug design.