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Synthesis of heteroaryl substituted α-mercapto acids from thiomalic acid using hexafluoroacetone as protecting and activating reagent

✍ Scribed by Ksenia Pumpor; Elisabeth Windeisen; Klaus Burger

Publisher: Journal of Heterocyclic Chemistry
Year: 2003
Tongue: English
Weight: 99 KB
Volume: 40
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570400306

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✦ Synopsis

Abstract

The synthesis of heterocyclic α‐mercapto acids starting from (RS)‐thiomalic acid using hexafluoroacetone as protecting and activating agent is described. The new compounds are useful building blocks for peptide and depsipeptide modification as well as for drug design.

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