Familial adenomatous polyposis (FAP) represents a human model of the adenomasarcinoma sequence. Colectomy substantially reduces the cancer risk. Restorative proctocolectomy maintains continence and abolishes the risk of rectal cancer, but there is a price to pay in terms of an increased morbidity ra
Hepatocellular adenoma in a male with familial adenomatous polyposis coli
β Scribed by Okamura, Yukiyasu ;Maeda, Atsuyuki ;Matsunaga, Kazuya ;Kanemoto, Hideyuki ;Furukawa, Hiroyoshi ;Sasaki, Keiko ;Yamaguchi, Shigeki ;Uesaka, Katsuhiko
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 274 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0944-1166
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Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua
## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm