𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli

✍ Scribed by Li-Kuo Su; Eddie K. Abdalla; Calvin H. L. Law; Wendy Kohlmann; Asif Rashid; Jean-Nicolas Vauthey


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
567 KB
Volume
92
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Mutation analysis of the adenomatous pol
✍ Marie Luise Bisgaard; RASMUS S. Ripa; Steffen BΓΌlow πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 26 KB πŸ‘ 2 views

## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm

Characterization of two novel adenomatou
✍ Bharati Bapat; Terri Berk; Angela Mitri; Zane Cohen; Steven Gallinger; Hartley S πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 English βš– 398 KB πŸ‘ 2 views

Patients with Familial Adenomatous Polyposis (FAP) manifest numerous colorectal adenomas as well as benign and malignant extra-colonic lesions. Adenomatous polyposis coli (APC) gene mutations are the underlying genetic defect in FAP. We analyzed germline D N A of 81 unrelated FAP patients and evalua

Familial adenomatous polyposis coli: Fiv
✍ Maria I. Scarano; Marina De Rosa; Luigi Panariello; Nicola Carlomagno; Gabriele πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 74 KB πŸ‘ 2 views

## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with

Cranial desmoid tumor associated with ho
✍ Deepthi C. de Silva; Morag F. Wright; David A. J. Stevenson; Caroline Clark; Eli πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 502 KB

## BACKGROUND. Familial adenomatous polyposis (FAP) is a dominantly inherited disorder characterized by the presence of more than 100 adenomatous polyps in the colon and rectum starting in the second decade of life. FAP is associated with extra colonic manifestations, including desmoid tumors.

Hypermethylation of the APC (adenomatous
✍ Mikko O. Hiltunen; Leena Alhonen; Jari Koistinaho; Sanna MyΓΆhΓ€nen; Matti PÀÀkkΓΆn πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 French βš– 206 KB πŸ‘ 2 views

Germline mutations of the putative tumor suppressor gene APC are associated in high frequency with the familial adenomatous polyposis, predisposing the patients to colorectal neoplasia. Similarly, sequence analyses have revealed that in more than half of patients with sporadic colorectal carcinoma o

Mutation analysis of the adenomatous pol
✍ Clara Ruiz-Ponte; Ana Vega; Angel Carracedo; Francisco Barros πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 26 KB πŸ‘ 2 views

Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T