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Hemodynamic Characteristics and Predictors of Pulmonary Hypertension in Patients With Sickle Cell Disease

✍ Scribed by Melissa C. Caughey; Alan L. Hinderliter; Susan K. Jones; Sanjeev P. Shah; Kenneth I. Ataga


Book ID
113448740
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
451 KB
Volume
109
Category
Article
ISSN
0002-9149

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In patients with sickle cell disease, anemia is a recognized risk factor for stroke, death, and the development of pulmonary hypertension. We have proposed that hemolytic anemia results in endothelial dysfunction and vascular instability and can ultimately lead to a proliferative vasculopathy leadin