## Abstract Existing standard methods of linkage analysis for quantitative phenotypes rest on the assumptions of either ordinary least squares (Haseman and Elston [1972] Behav. Genet. 2:3โ19; Sham and Purcell [2001] Am. J. Hum. Genet. 68:1527โ1532) or phenotypic normality (Almasy and Blangero [1998
Haseman and Elston Sib-Pair Linkage Analysis: A Brief Historical Note
โ Scribed by John C. DeFries
- Book ID
- 106359806
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 82 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0001-8244
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When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coeff
For each marker locus and for every pair of sibs with data available in the 1983 workshop data, the proportion of genes identical by descent was estimated. The mean proportions were compared between concordant and discordant sib pairs, and the mean proportion for concordantly affected pairs was comp