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Glutamatergic neurotransmission in a mouse model of Niemann–Pick Type C Disease

✍ Scribed by Giovanna D'Arcangelo; Daniele Grossi; Giovanna De Chiara; Maria Chiara de Stefano; Giancarlo Cortese; Gennaro Citro; Stefano Rufini; Virginia Tancredi; Daniela Merlo; Claudio Frank

Book ID
113505657
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
609 KB
Volume
1396
Category
Article
ISSN
0006-8993

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Decreased purinergic inhibition of synap
Decreased purinergic inhibition of synaptic activity in a mouse model of Niemann-Pick disease type C
✍ Su-ya Zhou; Shu-jun Xu; Ying-gang Yan; Hui-mei Yu; Shu-cai Ling; Jian-hong Luo 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 715 KB

## Abstract Niemann‐Pick disease type C (NPC) is a progressive neurodegenerative disorder characterized by accumulation of free cholesterol in lysosomes, mainly due to a mutation in the NPC1 gene. The pathophysiological basis of the neural disorders in NPC, however, is not well understood. We found