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Specific neural cell death in the mouse model of niemann-pick disease type C

✍ Scribed by Atsuko Yamada; Makoto Saji; Haruaki Ninomiya; Kousaku Ohno


Book ID
117365229
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
78 KB
Volume
31
Category
Article
ISSN
0168-0102

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## Abstract Niemann‐Pick disease type C (NPC) is a progressive neurodegenerative disorder characterized by accumulation of free cholesterol in lysosomes, mainly due to a mutation in the NPC1 gene. The pathophysiological basis of the neural disorders in NPC, however, is not well understood. We found