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Cyclodextrins in the treatment of a mouse model of Niemann-Pick C disease

✍ Scribed by Fernando Camargo; Robert P. Erickson; William S. Garver; G.Showkat Hossain; Peter N. Carbone; Randall A. Heidenreich; James Blanchard


Book ID
117173243
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
138 KB
Volume
70
Category
Article
ISSN
0024-3205

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## Abstract The BALB/c mouse model of Niemann‐Pick type C (NPC) disease exhibits neuropathological similarities to the human condition. There is an age‐related cerebral atrophy, demyelination of the corpus callosum, and degeneration of cerebellar Purkinje cells in the NPC mouse. In human NPC, many

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