𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease

✍ Scribed by Myung Sik Lee; Chul Hyoung Lyoo; Ismo Ulmanen; Ann-Christine Syvänen; Juha O Rinne

Book ID
117471394
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
85 KB
Volume
298
Category
Article
ISSN
0304-3940

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Genetic polymorphism of catechol-O-methy
Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic–pharmacodynamic pattern in patients with Parkinson's disease
✍ Manuela Contin; Paolo Martinelli; Mirella Mochi; Roberto Riva; Fiorenzo Albani; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from

Catechol-O-methyltransferase inhibitors:
Catechol-O-methyltransferase inhibitors: Clinical potential in the treatment of Parkinson's disease
✍ Jasper Dingemanse 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB 👁 2 views

Substitution therapy with levodopa and a peripheral inhibitor of aromatic L-amino acid decarboxylase (AADC) is the cornerstone in the treatment of Parkinson's disease. Chronic therapy with levodopa, however, is associated with the occurrence of motor complications that are partially related to the p