## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease
✍ Scribed by M. Yamamoto; M. Yokochi; S. Kuno; Y. Hattori; Y. Tsukamoto; H. Narabayashi; H. Tohgi; Y. Mizuno; H. Kowa; N. Yanagisawa; I. Kanazawa
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 517 KB
- Volume
- 104
- Category
- Article
- ISSN
- 1435-1463
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In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari
## Abstract In this 12‐week, randomized, open‐label, blinded‐rater, parallel‐group trial, the efficacy, safety, and tolerability of tolcapone and pergolide were compared in parkinsonian patients with a fluctuating response to levodopa. Patients received tolcapone 100 mg three times daily (t.i.d.),