Five patients with severe Parkinson's disease were characterized with respect to their pharmacokinetic and pharmacodynamic responses to levodopa given: orally, intravenously (three different infusion rates) and intraduodenally. The best therapeutic infusion rate in the intravenous study was used for
Effect of age on the pharmacokinetics of oral levodopa in patients with Parkinson's disease
β Scribed by M. Contin; R. Riva; P. Martinelli; F. Albani; A. Baruzzi
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 436 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari
## Abstract The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinsonβs disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the s