𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical and pharmacokinetic comparison of oral and duodenal delivery of levodopa/carbidopa in patients with Parkinson's disease with a fluctuating response to levodopa

✍ Scribed by D. Deleu; G. Ebinger; Y. Michotte


Publisher
Springer
Year
1991
Tongue
English
Weight
634 KB
Volume
41
Category
Article
ISSN
0031-6970

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Oral solution of levodopa ethylester for
✍ Ruth Djaldetti; Rivkah Inzelberg; Nir Giladi; Amos D. Korczyn; Yehudit Peretz-Ah 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

## Abstract Levodopa ethylester (LDEE), a highly soluble prodrug of levodopa, may overcome the impaired absorption of regular levodopa, due mainly to a combination of levodopa's poor solubility and delayed gastric emptying. We conducted a double‐blind, levodopa‐controlled, multicenter study of oral

Gait analysis in patients with Parkinson
✍ John D. O'Sullivan; Catherine M. Said; Louise C. Dillon; Marion Hoffman; Dr. And 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 727 KB

## Abstract Although clinical rating scales and simple timed tests of motor function are widely used to assess motor response to therapy, gait analysis may provide an alternative measure of this response. We studied 15 patients with PD complicated by motor fluctuations, first to determine changes i

Genetic polymorphism of catechol-O-methy
✍ Manuela Contin; Paolo Martinelli; Mirella Mochi; Roberto Riva; Fiorenzo Albani; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB

## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from

Effect of entacapone, a COMT inhibitor,
✍ V. V. Myllylä; K. A. Sotaniemi; A. Illi; K. Suominen; T. Keränen 📂 Article 📅 1993 🏛 Springer 🌐 English ⚖ 563 KB

In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari

Study of istradefylline in patients with
✍ Robert A. Hauser; Lisa M. Shulman; Joel M. Trugman; John W. Roberts; Akihisa Mor 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 150 KB 👁 1 views

## Abstract The objective of this study was to evaluate the efficacy, safety, and tolerability of istradefylline 20 mg once daily versus placebo as an adjunct to levodopa in subjects with Parkinson's disease (PD) who have motor fluctuations. Istradefylline (KW‐6002) is an adenosine A~2A~ receptor a