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Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson’s disease

✍ Scribed by Thomas Müller; Dirk Woitalla; Siegfried Muhlack


Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
203 KB
Volume
383
Category
Article
ISSN
0028-1298

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## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from