## Abstract We explored the potential effect of catechol‐__O__‐methyltransferase (COMT) genetic polymorphism on the pharmacokinetics and pharmacodynamics of a standard oral dose of levodopa in patients with Parkinson's disease (PD). We prospectively collected blood samples for COMT genotyping from
✦ LIBER ✦
The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson's disease
✍ Scribed by M. Białecka; M. Droździk; G. Kłodowska-Duda; K. Honczarenko; B. Gawrońska-Szklarz; G. Opala; J. Stankiewicz
- Book ID
- 109337101
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 121 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0001-6314
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In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari