## Abstract The stressβactivated protein kinase/__c__βJun __N__βterminal kinase (SAPK/JNK) pathway is a wellβknown senescenceβrelated stress activated protein kinase. Multiple environmental stresses induce programmed cell death, such as apoptosis. Normal human diploid fibroblast (HDF) cells have a
Genomic and proteomic profiling of oxidative stress response in human diploid fibroblasts
β Scribed by Lifang Xie; Ritu Pandey; Beibei Xu; George Tsaprailis; Qin M. Chen
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 996 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1389-5729
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Submicromolar concentrations of tributyltin (TBT), a commercially used organotin compound, were found to induce the expression of several stress proteins, most notably HSP89 and HSP70, in IMK-90 human diploid fibroblasts in a time-and dose-dependent manner. This induction can be demowtrated by quant
FrdnCiSCo, and letterman Army I n M u t e of Recearch, Presidio of S a n Francisco, California 94 129-6800 The stress, or heat shock response of eukaryotic cells is characterized by dramatic changes in the metabolism of respondingcells, most notably the increased synthesis o f a group of proteins k