Interactions with antidepressants, as well as other biochemical evidence, implicate the serotonin transporter 5-HTT in the etiology of affective disorders. However, genetic studies have produced conflicting results concerning an association of 5-HTT with bipolar disorder. We examined a variable numb
Genetic variation of the 5-HT2Areceptor gene and bipolar affective disorder
✍ Scribed by Blanca Gutiérrez; Jaume Bertranpetit; David Collier; María J. Arranz; Vicenç Vallès; Roser Guillamat; Jim van Os; L. Fañanás
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 22 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of central nervous functions by activating multiple 5-HT receptor subtypes. A possible irregularity of serotonergic neurotransmission has been implicated in a variety of neuropsychiatric diseases. In the present s
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individua
Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein ␣ subunit gene G␣z (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation po
Genetic factors seem to play an important role in the pathogenesis of affective disorder. The candidate gene strategies are being used, among others, to identify the genes conferring vulnerability to the disease. The genes coding for the receptors of gammaaminobutyric acid (GABA) have been proposed