Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder
✍ Scribed by Rami Abou Jamra; Katrin Klein; Angela Wolf Villela; Tim Becker; Thomas G. Schulze; Christine Schmael; Monika Deschner; Norman Klopp; Thomas Illig; Peter Propping; Sven Cichon; Marcella Rietschel; Markus M. Nöthen; Johannes Schumacher
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 55 KB
- Volume
- 141B
- Category
- Article
- ISSN
- 1552-4841
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Genetic factors seem to play an important role in the pathogenesis of affective disorder. The candidate gene strategies are being used, among others, to identify the genes conferring vulnerability to the disease. The genes coding for the receptors of gammaaminobutyric acid (GABA) have been proposed
## Abstract The phosphodiesterase 4B (PDE4B), which is involved in cognitive function in animal models, is a candidate susceptibility gene for schizophrenia (SZ) and bipolar disorder (BP). Variations in __PDE4B__ have previously been associated with SZ, with a suggested gender‐specific effect. We h