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Genetic characterization of CHO production host DG44 and derivative recombinant cell lines

✍ Scribed by M. Derouazi; D. Martinet; N. Besuchet Schmutz; R. Flaction; M. Wicht; M. Bertschinger; D.L. Hacker; J.S. Beckmann; F.M. Wurm

Book ID
116292087
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
636 KB
Volume
340
Category
Article
ISSN
0006-291X

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## Abstract The proteolytic activities expressed by a Chinese hamster ovary (CHO) cell line in the cultivation supernatant during the production of recombinant factor VIII were mapped with a broad spectrum protease assay and a series of different types of protease inhibitors. The destabilizing effe