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Characterisation of recombinant CHO cell lines by investigation of protein productivities and genetic parameters

✍ Scribed by Christine Lattenmayer; Evelyn Trummer; Kornelia Schriebl; Karola Vorauer-Uhl; Dethardt Mueller; Hermann Katinger; Renate Kunert

Book ID
118471861
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
482 KB
Volume
128
Category
Article
ISSN
0168-1656

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## Abstract In this study we compare the cellular control of recombinant human IgG~4~ monoclonal antibody (Mab) synthesis in different CHO cell lines. Based on comprehensive empirical analyses of mRNA and polypeptide synthetic intermediates we constructed cell line‐specific mathematical models of r