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Speeding up the production of recombinant proteins by CHO cells

✍ Scribed by Peter Gray; Warren Pilbrough; Guiseppe Codamo; Trent Munro

Book ID
118472840
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
52 KB
Volume
136
Category
Article
ISSN
0168-1656

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## Abstract In this study we compare the cellular control of recombinant human IgG~4~ monoclonal antibody (Mab) synthesis in different CHO cell lines. Based on comprehensive empirical analyses of mRNA and polypeptide synthetic intermediates we constructed cell line‐specific mathematical models of r