Effects of glutamine and asparagine on recombinant antibody production using CHO-GS cell lines
β Scribed by Xu, Ping; Dai, Xiao-Ping; Graf, Erica; Martel, Richard; Russell, Reb
- Book ID
- 126679855
- Publisher
- American Institute of Chemical Engineers
- Year
- 2014
- Tongue
- English
- Weight
- 939 KB
- Volume
- 30
- Category
- Article
- ISSN
- 8756-7938
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We previously compared changes in individual protein abundance between the proteomes of GS-NS0 cell lines with varying rates of cell-specific recombinant monoclonal antibody production (qMab). Here we extend analyses of our proteomic dataset to statistically determine if particular cell lines have d
## Abstract Presented is an antibody production platform based on the fedβbatch culture of recombinant NS0βderived cell lines. NS0 host cells, obtained from the European Collection of Cell Cultures (ECACC, Salisbury, UK, Part No. 85110503), were first adapted to grow in a proteinβfree, cholesterolβ