## Abstract In this study we compare the cellular control of recombinant human IgG~4~ monoclonal antibody (Mab) synthesis in different CHO cell lines. Based on comprehensive empirical analyses of mRNA and polypeptide synthetic intermediates we constructed cell lineβspecific mathematical models of r
A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies
β Scribed by Minsoo Kim; Peter M. O'Callaghan; Kurt A. Droms; David C. James
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 321 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0006-3592
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