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Genetic and clinical characteristics of maturity-onset diabetes of the young

✍ Scribed by Fernando M. A. Giuffrida; André F. Reis

Book ID
109044200
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
90 KB
Volume
7
Category
Article
ISSN
1462-8902

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## Maturity -onset diabetes of the young (MODY) can be defined by the clinical characteristics of early-onset Type 2 (non-insulin-dependent) diabetes and autosomal dominant inheritance. Mutations in four genes have been shown to cause MODY: glucokinase, hepatic nuclear factor 1 alpha (HNF1␣), hepa

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A mild form of diabetes in young people was recognized in the pre-insulin era but was forgotten, probably because of Joslin's dictum that all young people with diabetes should have insulin as a safeguard against complications. After the introduction of sulphonylureas in the 1950s it was found, most