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Newly Defined Genetic Diabetes Syndromes: Maturity Onset Diabetes of the Young

✍ Scribed by William E. Winter


Book ID
110411636
Publisher
Springer
Year
2003
Tongue
English
Weight
95 KB
Volume
4
Category
Article
ISSN
1389-9155

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✍ Hattersley, A.T. πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 127 KB πŸ‘ 1 views

## Maturity -onset diabetes of the young (MODY) can be defined by the clinical characteristics of early-onset Type 2 (non-insulin-dependent) diabetes and autosomal dominant inheritance. Mutations in four genes have been shown to cause MODY: glucokinase, hepatic nuclear factor 1 alpha (HNF1␣), hepa

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A mild form of diabetes in young people was recognized in the pre-insulin era but was forgotten, probably because of Joslin's dictum that all young people with diabetes should have insulin as a safeguard against complications. After the introduction of sulphonylureas in the 1950s it was found, most