๐”– Bobbio Scriptorium
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HLA and maturity onset diabetes of the young

โœ Scribed by A. Arnaiz-Villena; R. Barrio Castellanos; J. Argente Oliver; M. Alonso Blanco


Publisher
Springer
Year
1983
Tongue
English
Weight
89 KB
Volume
24
Category
Article
ISSN
0012-186X

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A mild form of diabetes in young people was recognized in the pre-insulin era but was forgotten, probably because of Joslin's dictum that all young people with diabetes should have insulin as a safeguard against complications. After the introduction of sulphonylureas in the 1950s it was found, most

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## Maturity -onset diabetes of the young (MODY) can be defined by the clinical characteristics of early-onset Type 2 (non-insulin-dependent) diabetes and autosomal dominant inheritance. Mutations in four genes have been shown to cause MODY: glucokinase, hepatic nuclear factor 1 alpha (HNF1โฃ), hepa