Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patients
β Scribed by Xu, Jian Yu; Dan, Qing Hong; Chan, Vivian; Wat, Nelson M S; Tam, Sidney; Tiu, Sau Cheung; Lee, Ka Fai; Siu, Shing Chung; Tsang, Man Wo; Fung, Lai Ming
- Book ID
- 110026152
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 109 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1018-4813
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## Maturity -onset diabetes of the young (MODY) can be defined by the clinical characteristics of early-onset Type 2 (non-insulin-dependent) diabetes and autosomal dominant inheritance. Mutations in four genes have been shown to cause MODY: glucokinase, hepatic nuclear factor 1 alpha (HNF1β£), hepa
A mild form of diabetes in young people was recognized in the pre-insulin era but was forgotten, probably because of Joslin's dictum that all young people with diabetes should have insulin as a safeguard against complications. After the introduction of sulphonylureas in the 1950s it was found, most