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Genetic analysis workshop III: Multipoint linkage analysis using FAP

โœ Scribed by Max P. Baur; Meinhard Neugebauer; Martin Sigmund


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
141 KB
Volume
2
Category
Article
ISSN
0741-0395

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โœฆ Synopsis


The family analysis package (FAP), originally designed for the analysis of the multilocus pedigree data of the 9th HLA workshop, was applied to the problem of multipoint mapping and estimation from the simulated data of GAW III. The fourpoint analyses performed within the two identified linkage groups yielded correct results.


๐Ÿ“œ SIMILAR VOLUMES


Genetic analysis workshop III: Multilocu
โœ D. T. Bishop; L. A. Cannon; S. J. Hasstedt; M. H. Skolnick ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 129 KB ๐Ÿ‘ 1 views

Two linkage groups were identified through pairwise linkage analysis using PAP. Three-locus analysis confirmed the suggested order of the loci within the linkage groups and was used to assess the strength of the conclusions. Strategies for improving the efficiency of linkage analysis are discussed.

Genetic analysis workshop III: Two-point
โœ M. Anne Spence; Mary L. Marazita; Susan E. Hodge ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 131 KB ๐Ÿ‘ 1 views

A three-ste;, procedure was employed to analyze the workshop data. Pairwise lod scores were computed using LIPED and were utilized for estimating the recombination frequencies and thereby the order among loci. This approach proved sugcient to identify accurately and to order the two linkage groups.

Genetic analysis workshop II: Segregatio
โœ Dr. Kadambari K. Namboodiri; Ellen B. Kaplan ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 276 KB ๐Ÿ‘ 1 views

Familial segregation and linkage analyses were performed on two sets of the Genetic Analyses Workshop II data. The salient features of the mode of inheritance of the disease trait and its linkage/association with polymorphic markers and also marker-marker linkages were delineated using statistical-g

Genetic analysis workshop III: Simple me
โœ N. Risch ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 130 KB ๐Ÿ‘ 1 views

Linkage groups and orders are established through two-point analysis; gene order is verified through simple three-point analysis; linkage maps are obtained through weighted least squares, fitting observed 8 values to those predicted by a parametric mapping function.

Genetic analysis workshop III: Two-point
โœ Nancy J. Cox; Brian K. Suarez ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 118 KB ๐Ÿ‘ 1 views

Two-point linkage analyses yielded correct identification of linkage groups and good estimates of recombination frequencies in both males and females. Additional analyses compared various family structures for the total number of typed individuals necessary to detect linkage. Results suggest that fo