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Genetic analysis workshop II: Segregation and linkage analysis

โœ Scribed by Dr. Kadambari K. Namboodiri; Ellen B. Kaplan


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
276 KB
Volume
1
Category
Article
ISSN
0741-0395

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โœฆ Synopsis


Familial segregation and linkage analyses were performed on two sets of the Genetic Analyses Workshop II data. The salient features of the mode of inheritance of the disease trait and its linkage/association with polymorphic markers and also marker-marker linkages were delineated using statistical-genetic techniques.


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Genetic analysis workshop II: Segregatio
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Data simulated for Genetic Analysis Workshop I1 were analyzed using PAP. Segregation analysis showed a simple recessive mode of inheritance for data set 2 while no conclusions could be made about the mode of inheritance for data set 3 . Pairwise linkage analysis suggested three linkage groups, but

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A combined segregation, linkage, and association analysis using the program COMBIN was performed on the simulated pedigree data prepared for the Second Genetic Analysis Workshop. The model used in COMBIN is described and the presented results illustrate its effectiveness in the analysis of such data

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The workshop data were examined using a newly developed methodology (MIL-INK, Risch, 1984) for combined segregation, linkage, and association analysis of a complex disease trait in pedigree data. Results from problems two and three suggest that the method is powerful both for determining mode of dis

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We analyzed disease-marker associations in Problem 3 for the Genetic Analysis Workshop 11, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 19841. Certain features that we added

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Genetic Analysis Workshop I1 Problems 2 and 3 were analyzed using the segregation analysis program POINTER and the linkage analysis program LIPED. Results of the segregation analyses were acceptable with respect to both parameter estimation and hypothesis testing. Results of the linkage analyses wer