✦ LIBER ✦

Genetic analysis workshop II: Segregation and three-locus linkage analysis

✍ Scribed by D. T. Bishop; L. A. Cannon; S. J. Hasstedt; M. H. Skolnick

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 225 KB
Volume: 1
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370010207

No coin nor oath required. For personal study only.

✦ Synopsis

Data simulated for Genetic Analysis Workshop I1 were analyzed using PAP. Segregation analysis showed a simple recessive mode of inheritance for data set 2 while no conclusions could be made about the mode of inheritance for data set 3 .

Pairwise linkage analysis suggested three linkage groups, but three-locus analysis did not provide strong evidence for the gene order within these groups. For three of the four three-locus comparisons performed, three-locus analysis suggested the simulated order. In only one case did the pairwise analysis suggest the simulated order, indicating the necessity for multi-locus analysis for gene order.

📜 SIMILAR VOLUMES

Genetic analysis workshop II: Multiple-l

Genetic analysis workshop II: Multiple-locus segregation analysis incorporating linkage markers

✍ N. Risch 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB 👁 1 views

The workshop data were examined using a newly developed methodology (MIL-INK, Risch, 1984) for combined segregation, linkage, and association analysis of a complex disease trait in pedigree data. Results from problems two and three suggest that the method is powerful both for determining mode of dis

Genetic analysis workshop II: Segregatio

Genetic analysis workshop II: Segregation and linkage analysis

✍ Dr. Kadambari K. Namboodiri; Ellen B. Kaplan 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 1 views

Familial segregation and linkage analyses were performed on two sets of the Genetic Analyses Workshop II data. The salient features of the mode of inheritance of the disease trait and its linkage/association with polymorphic markers and also marker-marker linkages were delineated using statistical-g

Genetic analysis workshop II: Combined s

Genetic analysis workshop II: Combined segregation, linkage, and association analysis

✍ N. E. Morton; S. L. Sherman; C. J. Maclean; S. Yee; R. Lew 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 259 KB 👁 1 views

A combined segregation, linkage, and association analysis using the program COMBIN was performed on the simulated pedigree data prepared for the Second Genetic Analysis Workshop. The model used in COMBIN is described and the presented results illustrate its effectiveness in the analysis of such data

Genetic analysis workshop II: Further co

Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

✍ Dr. P. L. Kramer; D. B. Altmann; K. K. Kidd 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 1 views

We analyzed disease-marker associations in Problem 3 for the Genetic Analysis Workshop 11, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 19841. Certain features that we added

Genetic analysis workshop III: Multipoin

Genetic analysis workshop III: Multipoint linkage analysis

✍ C. E. Aston; Dr. S. R. Wilson 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 1 views

Genetic analysis workshop II: Results of

Genetic analysis workshop II: Results of segregation analyses using POINTER and linkage analyses using LIPED

✍ Nancy J. Cox 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 225 KB 👁 1 views

Genetic Analysis Workshop I1 Problems 2 and 3 were analyzed using the segregation analysis program POINTER and the linkage analysis program LIPED. Results of the segregation analyses were acceptable with respect to both parameter estimation and hypothesis testing. Results of the linkage analyses wer