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Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

โœ Scribed by Dr. P. L. Kramer; D. B. Altmann; K. K. Kidd

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
271 KB
Volume
1
Category
Article
ISSN
0741-0395

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โœฆ Synopsis

We analyzed disease-marker associations in Problem 3 for the Genetic Analysis Workshop 11, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 19841. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker-trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

๐Ÿ“œ SIMILAR VOLUMES

Genetic analysis workshop II: Results of
Genetic analysis workshop II: Results of segregation analyses using POINTER and linkage analyses using LIPED
โœ Nancy J. Cox ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 225 KB ๐Ÿ‘ 1 views

Genetic Analysis Workshop I1 Problems 2 and 3 were analyzed using the segregation analysis program POINTER and the linkage analysis program LIPED. Results of the segregation analyses were acceptable with respect to both parameter estimation and hypothesis testing. Results of the linkage analyses wer