The family analysis package (FAP), originally designed for the analysis of the multilocus pedigree data of the 9th HLA workshop, was applied to the problem of multipoint mapping and estimation from the simulated data of GAW III. The fourpoint analyses performed within the two identified linkage grou
Genetic analysis workshop III: Multilocus linkage analysis using PAP
โ Scribed by D. T. Bishop; L. A. Cannon; S. J. Hasstedt; M. H. Skolnick
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 129 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0741-0395
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โฆ Synopsis
Two linkage groups were identified through pairwise linkage analysis using PAP. Three-locus analysis confirmed the suggested order of the loci within the linkage groups and was used to assess the strength of the conclusions. Strategies for improving the efficiency of linkage analysis are discussed.
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Two-point linkage analyses yielded correct identification of linkage groups and good estimates of recombination frequencies in both males and females. Additional analyses compared various family structures for the total number of typed individuals necessary to detect linkage. Results suggest that fo
Data simulated for Genetic Analysis Workshop I1 were analyzed using PAP. Segregation analysis showed a simple recessive mode of inheritance for data set 2 while no conclusions could be made about the mode of inheritance for data set 3 . Pairwise linkage analysis suggested three linkage groups, but
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