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Genetic analysis workshop III: Two-point linkage analysis on pedigrees, nuclear families, and sibships

✍ Scribed by Nancy J. Cox; Brian K. Suarez

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 118 KB
Volume: 2
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370020215

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✦ Synopsis

Two-point linkage analyses yielded correct identification of linkage groups and good estimates of recombination frequencies in both males and females. Additional analyses compared various family structures for the total number of typed individuals necessary to detect linkage. Results suggest that for codominant markers with moderate recombination frequency, pedigrees may not provide substantial savings over nuclear families.

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