✦ LIBER ✦
Genetic analysis workshop III: Combining two-point analyses under the constraints of a linear map and a constant female/male distance ratio
✍ Scribed by Jurg Ott
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 109 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
For each pair of loci among the four loci in a linkage group, a two-point analysis was performed. It consisted of estimating means, variances, and correlation of male and female recombination fractions and approximating the joint likelihood by a bivariate normal density. The painvise results were assumed independent and combined. The resulting likelihood was maximized over five parameters: three map distances, a constant ratio of female-to-male distance, and the parameter in Felsenstein's mapping function.