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Genetic analysis of familial Alzheimer's disease: The APP gene, chromosome 21 and chromosome 19


Book ID
122656980
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
386 KB
Volume
13
Category
Article
ISSN
0197-4580

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Susceptibility genes for familial Alzhei
โœ Dr. Lindsay A. Farrer; Ligaya Stice ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 356 KB

Linkage data from 92 FAD kindreds were analyzed by lod score analysis under various assumptions of disease penetrance, marker allele frequencies, and heterogeneity. Multilocus linkage analysis supports the existence of a gene in 40%-65% of families with predominantly late-onset illness (after age 65