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Use of a chromosome 21 jump clone in linkage analysis of familial Alzheimer's disease (FAD)


Book ID
123186281
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
178 KB
Volume
11
Category
Article
ISSN
0197-4580

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๐Ÿ“œ SIMILAR VOLUMES


Linkage analysis of a complex disease: A
โœ Dr. R. J. Neuman; J. P. Rice; C. L. Hampe; T. E. Burroughs; S. O. Moldin ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 383 KB ๐Ÿ‘ 1 views

Evidence for linkage of the Alzheimer's gene to markers on chromosomes 19 and 2 1 was assessed using single-locus and two-locus models of inheritance. Families were divided into groups determined by their average age at onset. The youngest group produced higher lod scores for markers on chromosome 2

Exclusion of linkage to the pericentrome
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Alzheimer disease (AD) is a devastating neurodegenerative disease leading to global dementia. The familial form (FAD) has been linked to markers on chromosome 21 in some families, most tightly to the loci D21S16 and D21S13 located close to the centromere of the long arm. In other families the FAD mu