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Genetics of Alzheimer's disease: APP, APOE, and the chromosome 14 locus

✍ Scribed by Hardy, John

Book ID
124144655
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
179 KB
Volume
15
Category
Article
ISSN
0197-4580

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A family of Finnish descent with very-early-onset Alzheimer's disease has been identified. Genetic analysis of this family eliminated the amyloid precursor protein gene as the pathogenic locus, but strongly implicated a locus on chromosome 14q23.4 between D14S52 and D14S55. The early age at onset of