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Genetic analysis of chromosome 21 in relation to early onset Alzheimer's disease

Book ID: 122783840
Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 290 KB
Volume: 11
Category: Article
ISSN: 0197-4580
DOI: 10.1016/0197-4580(90)90830-S

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Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. T w o genes are responsible for the majority of cases of this subtype of AD. Mutations in the P-amyloid precursor protein (PAPP) gene on chromosome 21 have been shown to completely cosegregate with the disea