Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: A reality check
✍ Scribed by Dr. Lindsay A. Farrer; Ligaya Stice
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 356 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Linkage data from 92 FAD kindreds were analyzed by lod score analysis under various assumptions of disease penetrance, marker allele frequencies, and heterogeneity. Multilocus linkage analysis supports the existence of a gene in 40%-65% of families with predominantly late-onset illness (after age 65) on chromosome 19 between D 19s 13 and ATP 1 A3. Evidence for a second FAD gene on chromosome 21 is weaker and stems primarily from a few families with earlyonset disease. Our findings also indicate that choice of the genetic model for FAD and marker allele frequencies may be crucial to conclusions about linkage and heterogeneity.