Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation
β Scribed by Kitabayashi, I; Aikawa, Y; Yokoyama, A; Hosoda, F; Nagai, M; Kakazu, N; Abe, T; Ohki, M
- Book ID
- 110054755
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 239 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0887-6924
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CBP, which is located on 16p13 and encodes a transcriptional adaptor/coactivator protein, has been shown to fuse by the t(8;16)(p11;p13) translocation to MOZ on 8p11 in acute myeloid leukemia. We found a t(11;16)(q23;p13) in a child with therapy-related chronic myelomonocytic leukemia. Subsequent re
We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 1