We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 1
✦ LIBER ✦
RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13)
✍ Scribed by Ioannis Panagopoulos; Margareth Isaksson; Charlotta Lindvall; Magnus Björkholm; Tomas Ahlgren; Thoas Fioretos; Sverre Heim; Felix Mitelman; Bertil Johansson
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 346 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1045-2257
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We describe a boy with Fanconi anemia (FA) who developed acute lymphoblastic leukemia (ALL) (FAB-L1) followed by acute myeloid leukemia (AML) (FAB-M5) at relapse. The patient was diagnosed with early pre-B-cell ALL without preceding aplastic anemia and was treated with ALL-oriented chemotherapy whic