A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16)

✍ Scribed by Max Chaffanet; Marie-Joëlle Mozziconacci; Francisca Fernandez; Danielle Sainty; Marina Lafage-Pochitaloff; Daniel Birnbaum; Marie-Josèphe Pébusque

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 365 KB
• Volume: 26
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/(sici)1098-2264(199910)26:2<161::aid-gcc8>3.0.co;2-6

✦ Synopsis

We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 16p13 chromosomal regions. The breakpoints occur in the MOZ region encoding the acidic domain and in the 5' end of the CBP gene. These results provide further evidence for the multiple contribution of both MOZ and CBP genes in acute leukemias.