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RT-PCR analysis of acute myeloid leukemia with t(8;16)(p11;p13): Identification of a novel MOZ/CBP transcript and absence of CBP/MOZ expression

✍ Scribed by Ioannis Panagopoulos; Thoas Fioretos; Margareth Isaksson; Felix Mitelman; Bertil Johansson; Niklas Theorin; Gunnar Juliusson

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 613 KB
Volume: 35
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.10131

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## Abstract The t(8;16)(p11;p13), which is strongly associated with acute myeloid leukemia (AML) displaying monocytic differentiation, erythrophagocytosis by the leukemic cells, and a poor response to chemotherapy, fuses the __MOZ__ gene (8p11) with the __CBP__ gene (16p13). Although genomic rearra

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We report on a novel chromosomal aberration, inv(8)(p11q24), in an M5 acute myeloid leukemia. We show by fluorescence in situ hybridization and Southern blot analyses that a t(8;16)(p11;p13) is masked by this inversion. The translocation targets the MOZ gene from the 8p11 and the CBP gene from the 1