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Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer

✍ Scribed by Smith-Sørensen, B; Lind, G E; Skotheim, R I; Fosså, S D; Fodstad, Ø; Stenwig, A-E; Jakobsen, K S; Lothe, R A

Book ID
110067115
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
342 KB
Volume
21
Category
Article
ISSN
0950-9232

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## Abstract Promotor hypermethylation is a common event in human cancer. __O^6^‐Methylguanine‐DNA Methyltransferase__ (__MGMT__) is a gene involved in DNA repair, which is methylated in a variety of cancer types. In colorectal cancer and lung cancer, hypermethylation of __MGMT__ has been correlated