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Promoter Hypermethylation of the O6-Methylguanine DNA Methyltransferase Gene and Microsatellite Instability in Metastatic Melanoma

✍ Scribed by Kohonen-Corish, Maija R J; Cooper, Wendy A; Saab, Jawad; Thompson, John F; Trent, Ronald J A; Millward, Michael J

Book ID
110049097
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
101 KB
Volume
126
Category
Article
ISSN
0022-202X

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O 6 -Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20-30% of human tumor lines is tightly linked to methylati