๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

โœ Scribed by Grombacher, Thomas; Eichhorn, Uta; Kaina, Bernd


Book ID
110061487
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
326 KB
Volume
17
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


O6-methylguanine-DNA methyltransferase g
โœ Christine Rolhion; Frรฉdรฉrique Penault-Llorca; Jean-Louis Kemeny; Fabrice Kwiatko ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 169 KB ๐Ÿ‘ 2 views

Repair of cytotoxic DNA damage by O 6 -methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear

Inactivation of the DNA repair gene O6-m
โœ Yu-Jing Zhang; Yu Chen; Habibul Ahsan; Ruth M. Lunn; Po-Huang Lee; Chien-Jen Che ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 237 KB ๐Ÿ‘ 1 views

## Abstract O^6^โ€methylguanineโ€DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationโ€specific PCR (MSP)

DNA repair gene O6-methylguanine-DNA met
โœ Dong Yin; Dong Xie; Wolf-Karsten Hofmann; Wenxuan Zhang; Kamlesh Asotra; Rex Won ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 220 KB

## Abstract The DNA repair enzyme O^6^โ€methylguanineโ€DNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG

The P140K mutant of human O6-methylguani
โœ Lorna B. Woolford; Thomas D. Southgate; Geoffrey P. Margison; Michael D. Milsom; ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 155 KB

The O 6 -methylguanine-DNA-methyltransferase (MGMT) inactivator O 6benzylguanine (O 6 -beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxicity and a reduced maximum tolerated dose (MTD) for BC