p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents
โ Scribed by Grombacher, Thomas; Eichhorn, Uta; Kaina, Bernd
- Book ID
- 110061487
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 326 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
Repair of cytotoxic DNA damage by O 6 -methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear
## Abstract O^6^โmethylguanineโDNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationโspecific PCR (MSP)
## Abstract The DNA repair enzyme O^6^โmethylguanineโDNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG
The O 6 -methylguanine-DNA-methyltransferase (MGMT) inactivator O 6benzylguanine (O 6 -beG) is currently under clinical investigation as a potential tumour-sensitising agent. In clinical trials its use has been associated with increased myelotoxicity and a reduced maximum tolerated dose (MTD) for BC