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Frequent Loss of Heterozygosity for Chromosome 10 in Uterine Leiomyosarcoma in Contrast to Leiomyoma

✍ Scribed by Bradley J. Quade; Álvaro P. Pinto; Donald R. Howard; William A. Peters III; Christopher P. Crum


Book ID
117022656
Publisher
American Society for Investigative Pathology
Year
1999
Tongue
English
Weight
181 KB
Volume
154
Category
Article
ISSN
0002-9440

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Many tumors exhibit loss of heterozygosity (LOH) for polymorphic markers in regions of the genome that contain genes whose normal function can suppress tumor growth. Mapping of regions of LOH can help identify putative tumor suppressor loci that play a role in the pathogenesis of a disease. We evalu