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Frequent loss of heterozygosity in chromosomal region 9pter-p13 in tumor biopsies and cytological material of uterine cervical cancer

✍ Scribed by Maria M. Manolaraki; Demetrios A. Arvanitis; George Sourvinos; Stavros Sifakis; Eugenios Koumantakis; Demetrios A. Spandidos


Book ID
117467151
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
178 KB
Volume
176
Category
Article
ISSN
0304-3835

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## Abstract Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, __RASSF1A__ located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the sta